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Overview
This is one of the best Selling online book for quick review. It is very good book to study a day before your exam. It can also cover your paper as well as viva questions and will help you to score very high.
Features of Physeo Biochemistry PDF
Following are the features of Physeo Biochemistry PDF:
MEDICAL COURSE AND STEP 1 REVIEW
FIRST EDITION
Accompanies online videos taught by Rhett Thomson & Michael Christensen.
physeo . com
Table of Contents:
MOLECULAR …………………………………………………………………………………………………………4
Section I – DNA Replication ……………………………………………………………………………………………………………………………………… 4
Section II – DNA Repair …………………………………………………………………………………………………………………………………………… 7
Section III – Transcription …………………………………………………………………………………………………………………………………………. 9
Section IV – Translation ………………………………………………………………………………………………………………………………………….. 13
Section V – DNA Mutations …………………………………………………………………………………………………………………………………….. 15
CELLULAR …………………………………………………………………………………………………………..18
Section I – Cell Cycle ……………………………………………………………………………………………………………………………………………… 18
Section II – Cell Structure ……………………………………………………………………………………………………………………………………….. 21
Section III – Connective tissue …………………………………………………………………………………………………………………………………. 24
LABORATORY TECHNIQUES ……………………………………………………………………………..28
Section I – PCR ……………………………………………………………………………………………………………………………………………………… 28
Section II – Blotting Procedures ……………………………………………………………………………………………………………………………….. 30
Section III – Flow cytometry ……………………………………………………………………………………………………………………………………. 32
Section IV – Microarrays and ELISA ………………………………………………………………………………………………………………………… 34
Section V – Karyotyping and FISH …………………………………………………………………………………………………………………………… 36
Section VI – CRISPR/Cas9 & Molecular Cloning ………………………………………………………………………………………………………. 38
GENETICS …………………………………………………………………………………………………………….40
Section I – Genetics Overview …………………………………………………………………………………………………………………………………. 40
Section II – Imprinting and Uniparental Disomy ………………………………………………………………………………………………………… 45
Section III – Linkage Disequilibrium ………………………………………………………………………………………………………………………… 49
Section IV – Pedigrees…………………………………………………………………………………………………………………………………………….. 51
Section V – Hardy-Weinberg Principle ……………………………………………………………………………………………………………………… 54
Section VI – Autosomal Dominant Diseases ………………………………………………………………………………………………………………. 56
Section VI.1 – Autosomal Dominant Diseases ……………………………………………………………………………………………………………. 58
Section VII – X-linked Diseases……………………………………………………………………………………………………………………………….. 59
Section VII.1 – X-linked Recessive Diseases……………………………………………………………………………………………………………… 61
Section VII.2 – Rett Syndrome …………………………………………………………………………………………………………………………………. 62
Section VIII – Autosomal Recessive Diseases ……………………………………………………………………………………………………………. 63
Section IX – Trinucleotide Repeat Disorders ……………………………………………………………………………………………………………… 65
Section IX.1 – Huntington Disease …………………………………………………………………………………………………………………………… 68
Section IX.2 – Myotonic Dystrophy ………………………………………………………………………………………………………………………….. 69
Section IX.3 – Fragile X Syndrome ………………………………………………………………………………………………………………………….. 70
Section IX.4 – Friedreich Ataxia ………………………………………………………………………………………………………………………………. 71
Section X – Autosomal Trisomies …………………………………………………………………………………………………………………………….. 72
Section X.1 – Down Syndrome ………………………………………………………………………………………………………………………………… 76
Section X.2 – Edwards Syndrome …………………………………………………………………………………………………………………………….. 77
Section X.3 – Patau Syndrome …………………………………………………………………………………………………………………………………. 78
Section XI – Sex Chromosome Disorders ………………………………………………………………………………………………………………….. 79
Section XI.1 – Turner Syndrome ………………………………………………………………………………………………………………………………. 82
Section XI.2 – Klinefelter Syndrome ………………………………………………………………………………………………………………………… 83
Section XII – Deletion syndromes …………………………………………………………………………………………………………………………….. 84
Section XII.1 – Cri-du-chat ……………………………………………………………………………………………………………………………………… 86
Section XII.2 – Williams Syndrome ………………………………………………………………………………………………………………………….. 87
Section XII.3 – DiGeorge Syndrome…………………………………………………………………………………………………………………………. 88
METABOLISM ………………………………………………………………………………………………………91
Section I – Hexokinase & Glucokinase ……………………………………………………………………………………………………………………… 91
Section II – Glycolysis ……………………………………………………………………………………………………………………………………………. 93
Section III – Pyruvate Metabolism ……………………………………………………………………………………………………………………………. 96
Section IV – The Tricarboxylic Acid Cycle ……………………………………………………………………………………………………………….. 98
Section V – The Electron Transport Chain ……………………………………………………………………………………………………………….. 100
Section VI – Gluconeogenesis ………………………………………………………………………………………………………………………………… 102
Section VII – Glycogen …………………………………………………………………………………………………………………………………………. 104
Section VII.1 – Von Gierke & Cori …………………………………………………………………………………………………………………………. 107
Section VII.1 – Pompe & Mcardle ………………………………………………………………………………………………………………………….. 108
Section VIII – Fructose ………………………………………………………………………………………………………………………………………….. 109
Section IX – Galactose ………………………………………………………………………………………………………………………………………….. 112
Section X – Hexose Monophosphate Pathway ………………………………………………………………………………………………………….. 114
Section XI – Fatty Acid Metabolism ……………………………………………………………………………………………………………………….. 116
Section XII – Ketone Bodies ………………………………………………………………………………………………………………………………….. 119
Section XIII – Ethanol Metabolism …………………………………………………………………………………………………………………………. 121
Section XIV – Lipid Transport ……………………………………………………………………………………………………………………………….. 123
Section XV – Homocysteine Metabolism ………………………………………………………………………………………………………………… 126
Section XVI – Purines & Pyrimidines ……………………………………………………………………………………………………………………… 128
Section XVII – Ammonia ………………………………………………………………………………………………………………………………………. 131
Section XVIII – Amino Acids ………………………………………………………………………………………………………………………………… 134
Section XIX – Lysosomal Storage Diseases ……………………………………………………………………………………………………………… 137
Section XIX.1 – Tay-Sachs & Niemann-Pick Disease ……………………………………………………………………………………………….. 139
Section XIX.2 – Fabry Disease ………………………………………………………………………………………………………………………………. 140
Section XIX.3 – Metachromatic Leukodystrophy ……………………………………………………………………………………………………… 141
Section XIX.4 – Krabbe Disease …………………………………………………………………………………………………………………………….. 142
Section XIX.5 – Gaucher Disease …………………………………………………………………………………………………………………………… 143
Section XIX.6 – Hurler & Hunter Syndrome ……………………………………………………………………………………………………………. 144
Section XX – Nutrition ………………………………………………………………………………………………………………………………………….. 145
Section XX.1 – Thiamine ……………………………………………………………………………………………………………………………………… 147
Section XX.2 – Riboflavin (B2) …………………………………………………………………………………………………………………………….. 148
Section XX.3 – Niacin (B3) ………………………………………………………………………………………………………………………………….. 149
Section XX.4 – Pantothenic Acid (B5)……………………………………………………………………………………………………………………. 150
Section XX.5 – Pyridoxine (B6)…………………………………………………………………………………………………………………………….. 151
Section XX.6 – Biotin (B7) …………………………………………………………………………………………………………………………………… 152
Section XX.7 – Folate (B9) …………………………………………………………………………………………………………………………………… 153
Section XX.8 – Cobalamin (B12)…………………………………………………………………………………………………………………………… 154
Section XX.9 – Vitamin C …………………………………………………………………………………………………………………………………….. 155
Section XX.10 – Vitamin A …………………………………………………………………………………………………………………………………… 156
Section XX.11 – Vitamin D …………………………………………………………………………………………………………………………………… 157
Section XX.12 – Vitamin E …………………………………………………………………………………………………………………………………… 158
Section XX.13 – Vitamin K ……………………………………………………………………………………………………………………………………. 159
Section XX.14 – Zinc ……………………………………………………………………………………………………………………………………………. 160
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