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The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products. In this blog post, you will be able to download free PDF e-book copy of Anticancer Agents from Natural Products PDF.
Features of Anticancer Agents from Natural Products PDF
Here are important features of this book:
History of each covered drug?a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications
Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery
Important biosynthetic approaches to “unnatural” natural products
Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis?enabled by historic advances in methodology?has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future.
Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.
Table of Contents
Below is the complete table of contents presented in Anticancer Agents from Natural Products PDF:
Chapter 1 Introduction
Chapter 2 Camptothecin and Its Analogs
Chapter 3 The Discovery and Development of the Combretastatins
Chapter 4 Homoharringtonine and Related Compounds
Chapter 5 Podophyllotoxins and Analogs
Chapter 6 Taxol and Its Analogs
Chapter 7 The Vinca Alkaloids
Chapter 8 The Bryostatins
Chapter 9 The Isolation, Characterization, and Development of a Novel Class of Potent Antimitotic Macrocyclic Depsipeptides: The Cryptophycins
Chapter 10 Chemistry and Biology of the Discodermolides, Potent Mitotic Spindle Poisons….
Chapter 11 The Dolastatins: Novel Antitumor Agents from Dolabella auricularia
Chapter 12 Ecteinascidin-743 (Yondelis®), Aplidin®, and Irvalec®
Chapter 13 Discovery of E7389, A Fully Synthetic Macrocyclic Ketone Analog of Halichondrin B
Chapter 14 HTI-286 (Taltobulin), A Synthetic Analog of the Antimitotic Natural Product Hemiasterlin
Chapter15 The Actinomycins
Chapter16 Anthracyclines
Chapter17 Ansamitocins (Maytansinoids)
Chapter18 Benzoquinone Ansamycins
Chapter19 Bleomycin Group Antitumor Agents
Chapter20 Biochemical and Biological Evaluation of (+)-CC-1065 Analogs and Conjugates with Polyamides
Chapter21 Epothilone, A Myxobacterial Metabolite with Promising Antitumor Activity
Chapter22 Enediynes
Chapter23 The Mitomycins
Chapter24 Staurosporines and Structurally Related Indolocarbazoles as Antitumor Agents
Chapter25 Combinatorial Biosynthesis of Anticancer Natural Products
Chapter 26 Developments and Future Trends in Anticancer Natural Products Drug Discovery The Actinomycins
Below are the technical specifications of Anticancer Agents from Natural Products PDF.
Book Name : Anticancer Agents from Natural Products
Edition : 2nd Edition | | ISBN : 1439813825
Author Name : Gordon M Cragg; David G I Kingston; David J Newman;
Category : Medical
Format / Pages : PDF – 767 Pages
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