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As haemophilia is a life-long condition, continuing supervision by a group of medical personnel is required. In many countries this is provided by comprehensive care haemophilia centres where staff of all specialities concerned with treatment- haematologists, paediatricians, nurses, physiotherapists, orthopaedic surgeons – have specialized knowledge.This new book is a definitive resource on the current aspects and issues around haemophilia. Complications of haemophilia care are well covered in chapters on inhibitors, and musculoskeletal problems, as are all the latest developments in the field of haemophilia. Content: Chapter 1 History of Hemophilia (pages 1–5): Caroline Cromwell and Louis M. AledortChapter 2 Hemophilia Care in the Modern World (pages 6–9): Christine A. LeeChapter 3 Comprehensive Care Model in Hemophilia (pages 10–13): Prasad MathewChapter 4 When Should we Switch from On?Demand to Prophylaxis Regimen? (pages 15–20): Jose A. Aznar, Andres Moret, Lydia Abad?Franch, Ana R. Cid, Saturnino Haya and Felipe QuerolChapter 5 Prophylaxis in Children (pages 21–26): Marilyn J. Manco?JohnsonChapter 6 Prophylaxis in Adults with Hemophilia (pages 27–29): Victor Jimenez?Yuste, Emerito?Carlos Rodriguez?Merchan, Maria?Teresa Alvarez?Roman and Monica Martin?SalcesChapter 7 The Economics of Prophylaxis: Does Prophylaxis with Clotting Factor Represent Value for Money? (pages 30–34): Alec MinersChapter 8 The Transition of Care for the Young Adult Hemophilia Patient (pages 35–38): Pia PetriniChapter 9 Perinatal Clinical Care and Molecular Diagnosis in Hemophilia (pages 39–43): Carmen Altisent and Francisco VidalChapter 10 Managing the Mature Person with Hemophilia (pages 44–48): Savita Rangarajan and Thynn Thynn YeeChapter 11 Quality of Life in Hemophilia (pages 49–52): Eduardo RemorChapter 12 Immunology of Inhibitor Development (pages 53–59): Birgit M. Reipert, Christoph J. Hofbauer, Katharina N. Steinitz, Hans?Peter Schwarz and Frank M. HorlingChapter 13 Epidemiology of Inhibitors (pages 60–67): Johanna G. van der BomChapter 14 Early Tolerization to Minimize Inhibitors in PUPs with Hemophilia A (pages 68–73): Gunter Auerswald and Karin KurnikChapter 15 Prediction of Inhibitors in Severe Hemophilia (pages 74–78): H. Marijke van den Berg and Kathelijn FischerChapter 16 Genetic Basis for Inhibitor Development (pages 79–83): Johannes Oldenburg and Anna PavlovaChapter 17 Non?Genetic Risk Factors for Inhibitor Development (pages 84–88): Lisa N. Boggio and Mindy L. SimpsonChapter 18 Immune Tolerance Induction Programs (pages 89–96): Jan Blatny and Prasad MathewChapter 19 Prophylaxis in Hemophilia a Patients with Inhibitors (pages 97–101): Leonard A. Valentino and Guy YoungChapter 20 Treatment of Bleeding in FVIII Inhibitor Patients (pages 102–106): Paul L. F. Giangrande and Jerome TeitelChapter 21 Discordancy of Bypassing Therapy (pages 107–110): Jan AstermarkChapter 22 Experimental Studies on Hemarthrosis, Synovitis and Arthropathy (pages 111–116): Leonard A. Valentino and Narine HakobyanChapter 23 Assessment of Joint Involvement in Hemophilia (pages 117–120): Erik BerntorpChapter 24 Imaging of the Hemophilic Joint (pages 121–126): Carmen Martin?Hervas and Emerito?Carlos Rodriguez?MerchanChapter 25 Initial and Advanced Stages of Hemophilic Arthropathy, and Other Musculo?Skeletal Problems: The Role of Orthopedic Surgery (pages 127–132): Emerito?Carlos Rodriguez?Merchan, Victor Jimenez?Yuste and Nicholas J. GoddardChapter 26 Perioperative Thromboprophylaxis for Persons with Hemophilia Undergoing Orthopedic Surgery (pages 133–137): Gerard Dolan, Donna M. DiMichele and Emerito?Carlos Rodriguez?MerchanChapter 27 New Technologies for the Pharmacokinetic Improvement of Coagulation Factor Proteins (pages 139–145): Leonard A. ValentinoChapter 28 Current and Future Approaches to Gene Therapy in Patients with Hemophilia (pages 146–149): Maria?Teresa Alvarez?Roman, Monica Martin?Salces, Victor Jimenez?Yuste and Emerito?Carlos Rodriguez?MerchanChapter 29 New Developments in Hemophilic Arthropathy (pages 150–155): Emerito?Carlos Rodriguez?Merchan and Leonard A. ValentinoChapter 30 Physiotherapy Evaluation and Intervention in the Acute Hemarthrosis: Challenging the Paradigm (pages 156–161): Nichan Zourikian and Angela L. ForsythChapter 31 Laboratory Assays to Predict Response to Bypassing Agents (pages 162–166): Benny Sorensen and Claude NegrierChapter 32 Combination/Sequential Use of Bypassing Agents (pages 167–170): Alessandro Gringeri
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