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The Oxford Textbook of Medicine is the foremost international textbook of medicine. Unrivalled in its coverage of the scientific aspects and clinical practice of internal medicine and its subspecialties, it is a fixture in the offices and wards of physicians around the world , as well as being a key resource for medico legal practitioners. Accessible digitally with regular updates, as well as in print, readers are provided with multiple avenues of access depending on their need and preference.
More comprehensive, more authoritative, and more international than any other textbook; Oxford Textbook of Medicine focuses on offering both perspective and practical guidance on clinical management and prevention of disease.
Introductory sections focus on the patient experience, medical ethics and clinical decision making, outlining a philosophy which has always characterized the Oxford Textbook of Medicine. It is humane, thought provoking, and aims to instill in readers an understanding of the role of medicine in society and the contribution it can make to the health of populations, and it does not shy away from discussion of controversial aspects of modern medicine.
As always, there is detailed coverage of all areas of internal medicine by the world’s very best authors. The Oxford Textbook of Medicine seeks to embody advances in understanding and practice that have arisen through scientific research. The integration of basic science and clinical practice is unparalleled, and throughout the book the implications of research for medical practice are explained. The core clinical medicine sections offer in depth coverage of the traditional specialty areas. The Oxford Textbook of Medicine has unsurpassed detail on infectious diseases: the most comprehensive coverage to be found in any textbook of medicine. Other sections of note include stem cells and regenerative medicine; inequalities in health; medical aspects of pollution and climate change; travel and expedition medicine; bioterrorism and forensic medicine; pain; medical disorders in pregnancy; nutrition; and psychiatry and drug related problems in general medical practice. The section on acute medicine is designed to give rapid access to information when it is needed quickly.
In response to ongoing user feedback there have been substantial changes to ensure that the Oxford Textbook of Medicine continues to meet the needs of its readers. Chapter essentials give accessible overviews of the content and a new design ensures that the textbook is easy to read and navigate. The evidence base and references continue to be at the forefront of research.
New to this edition is that purchasers of the print version of the Oxford Textbook of Medicine sixth edition will have free access on Oxford Medicine Online to all the content plus regular updates for the life of the edition.
Table of Contents:
cover
Half title
Title
Copyright
Foreword
Perface
Section Editors
Contents
List of abbreviations xxxv
List of contributors xlv
Haematological disorders Section editors: Chris Hatton and Deborah Hay
22.1 Introduction to haematology 5169 Chris Hatton
22.2 Haematopoiesis 5172 22.2.1 Cellular and molecular basis of haematopoiesis 5172 Paresh Vyas and N. Asger Jakobsen
22.2.2 Diagnostic techniques in the assessment of haematological malignancies 5181 Wendy N. Erber
22.3 Myeloid disease 5189 22.3.1 Granulocytes in health and disease 5189 Joseph Sinning and Nancy Berliner
22.3.2 Myelodysplastic syndromes 5197 Charlotte K. Brierley and David P. Steensma
22.3.3 Acute myeloid leukaemia 5205 Nigel Russell and Alan Burnett
22.3.4 Chronic myeloid leukaemia 5213 Mhairi Copland and Tessa L. Holyoake†
22.3.5 The polycythaemias 5227 Daniel Aruch and Ronald Hoffman
22.3.6 Thrombocytosis and essential thrombocythaemia 5239 Daniel Aruch and Ronald Hoffman
22.3.7 Primary myelofibrosis 5247 Evan M. Braunstein and Jerry L. Spivak
22.3.8 Eosinophilia 5254 Peter F. Weller
22.3.9 Histiocytosis 5259 Chris Hatton
22.4 Lymphoid disease 5263 22.4.1 Introduction to lymphopoiesis 5263 Caron A. Jacobson and Nancy Berliner
22.4.2 Acute lymphoblastic leukaemia 5269 H. Josef Vormoor, Tobias F. Menne, and Anthony V. Moorman
22.4.3 Hodgkin lymphoma 5280 Vijaya Raj Bhatt and James O. Armitage
22.4.4 Non- Hodgkin lymphoma 5288 Vijaya Raj Bhatt and James O. Armitage
22.4.5 Chronic lymphocytic leukaemia 5302 Clive S. Zent and Aaron Polliack
22.4.6 Plasma cell myeloma and related monoclonal gammopathies 5310 S. Vincent Rajkumar and Robert A. Kyle
22.5 Bone marrow failure 5325 22.5.1 Inherited bone marrow failure syndromes 5325 Irene Roberts and Inderjeet S. Dokal
22.5.2 Acquired aplastic anaemia and pure red cell aplasia 5336 Judith C.W. Marsh, Shreyans Gandhi, and Ghulam J. Mufti
22.5.3 Paroxysmal nocturnal haemoglobinuria 5348 Lucio Luzzatto
22.6 Erythroid disorders 5354 22.6.1 Erythropoiesis 5354 Vijay G. Sankaran
22.6.2 Anaemia: pathophysiology, classification, and clinical features 5359 David J. Weatherall† and Chris Hatton
22.6.3 Anaemia as a challenge to world health 5366 David J. Roberts and David J. Weatherall†
22.6.4 Iron metabolism and its disorders 5371 Timothy M. Cox and John B. Porter
22.6.5 Anaemia of inflammation 5402 Sant- Rayn Pasricha and Hal Drakesmith
22.6.6 Megaloblastic anaemia and miscellaneous deficiency anaemias 5407 A.V. Hoffbrand
22.6.7 Disorders of the synthesis or function of haemoglobin 5426 Deborah Hay and David J. Weatherall†
22.6.8 Anaemias resulting from defective maturation of red cells 5450 Stephen J. Fuller and James S. Wiley
22.6.9 Disorders of the red cell membrane 5456 Patrick G. Gallagher
22.6.10 Erythrocyte enzymopathies 5463 Alberto Zanella and Paola Bianchi
22.6.11 Glucose- 6- phosphate dehydrogenase deficiency 5472 Lucio Luzzatto
22.6.12 Acquired haemolytic anaemia 5479 Amy Powers and Leslie Silberstein
22.7 Haemostasis 5490 22.7.1 The biology of haemostasis and thrombosis 5490 Gilbert C. White, II, Harold R. Roberts, and Nigel S. Key
22.7.2 Evaluation of the patient with a bleeding tendency 5509 Trevor Baglin
22.7.3 Thrombocytopenia and disorders of platelet function 5520 Nicola Curry and Susie Shapiro
22.7.4 Genetic disorders of coagulation 5532 Eleanor S. Pollak and Katherine A. High
22.7.5 Acquired coagulation disorders 5546 T.E. Warkentin
Transfusion and transplantation 5563 22.8.1 Blood transfusion 5563 D.S. Giovanniello and E.L. Snyder
22.8.2 Haemopoietic stem cell transplantation 5579 E.C. Gordon- Smith and Emma C. Morris
23.16 Cutaneous reactions to drugs 5752 Sarah Walsh, Daniel Creamer, and Haur Yueh Lee
23.17 Management of skin disease 5761 Rod Sinclair
SECTION 23 Disorders of the skin Section editor: Roderick J. Hay
23.1 Structure and function of skin 5591 John A. McGrath
23.2 Clinical approach to the diagnosis of skin disease 5596 Vanessa Venning
23.3 Inherited skin disease 5602 Thiviyani Maruthappu and David P. Kelsell
Thiviyani Maruthappu and David P. Kelsell 23.4 Autoimmune bullous diseases 5612 Kathy Taghipour and Fenella Wojnarowska
23.5 Papulosquamous disease 5621 Christopher E.M. Griffiths
23.6 Dermatitis/ eczema 5630 Peter S. Friedmann, Michael J. Arden- Jones, and Roderick J. Hay
23.7 Cutaneous vasculitis, connective tissue diseases, and urticaria 5639 Volha Shpadaruk and Karen E. Harman
23.8 Disorders of pigmentation 5677 Eugene Healy
23.9 Photosensitivity 5688 Hiva Fassihi and Jane McGregor
23.10 Infections of the skin 5695 Roderick J. Hay
23.11 Sebaceous and sweat gland disorders 5699 Alison M. Layton
23.12 Blood and lymphatic vessel disorders 5709 Peter S. Mortimer and Roderick J. Hay
23.13 Hair and nail disorders 5724 David de Berker
23.14 Tumours of the skin 5732 Edel O’Toole
23.15 Skin and systemic diseases 5743 Clive B. Archer and Charles M.G. Archer
SECTION 24 Neurological disorders Section editor: Christopher Kennard
Section editor: Christopher Kennard 24.1 Introduction and approach to the patient with neurological disease 5775 Alastair Compston and Christopher Kennard
24.2 Mind and brain: Building bridges between neurology, psychiatry, and psychology 5778 Adam Zeman
24.3 Clinical investigation of neurological disease 5781 24.3.1 Lumbar puncture 5781 R. Rhys Davies and Andrew J. Larner
24.3.2 Electrophysiology of the central and peripheral nervous systems 5785 Christian Krarup
24.3.3 Imaging in neurological diseases 5802 Andrew J. Molyneux, Shelley Renowden, and Marcus Bradley
24.3.4 Investigation of central motor pathways: Magnetic brain stimulation 5817 K.R. Mills
24.4 Higher cerebral function 5821 24.4.1 Disturbances of higher cerebral function 5821 Peter J. Nestor
24.4.2 Alzheimer’s disease and other dementias 5830 Jonathan M. Schott
Jonathan M. Schott 24.5 Epilepsy and disorders of consciousness 5860 24.5.1 Epilepsy in later childhood and adulthood 5860
24.5.2 Narcolepsy 5882 Matthew C. Walker
24.5.3 Sleep disorders 5886 Paul J. Reading
24.5.4 Syncope 5896 Andrew J. Larner
24.5.5 The unconscious patient 5901 David Bates
24.5.6 Brainstem death and prolonged disorders of consciousness 5908 Ari Ercole, Peter J. Hutchinson, and John D. Pickard
24.6 Disorders of the special senses 5913 24.6.1 Visual pathways 5913 Sara Ajina and Christopher Kennard
24.6.2 Eye movements and balance 5922 Michael Strupp and Thomas Brandt
24.6.3 Hearing loss 5931 Linda Luxon
24.7 Disorders of movement 5937 24.7.1 Subcortical structures: The cerebellum, basal ganglia, and thalamus 5937 Mark J. Edwards and Penelope Talelli
24.7.2 Parkinsonism and other extrapyramidal diseases 5946 Elisaveta Sokolov, Vinod K. Metta, and K. Ray Chaudhuri
24.7.3 Movement disorders other than Parkinson’s disease 5956 Bettina Balint and Kailash Bhatia
24.7.4 Ataxic disorders 5976 Nicholas Wood
24.8 Headache 5987 Peter J. Goadsby
24.9 Brainstem syndromes 6006 David Bates
24.10 Specific conditions affecting the central nervous system 6010 24.10.1 Stroke: Cerebrovascular disease 6010 J. van Gijn (revised by Peter M. Rothwell)
24.10.2 Demyelinating disorders of the central nervous system 6026 Alasdair Coles and Siddharthan Chandran
24.10.3 Traumatic brain injury 6042 Tim Lawrence and Laurence Watkins
24.10.4 Intracranial tumours 6048 Jeremy Rees
24.10.5 Idiopathic intracranial hypertension 6054 Alexandra Sinclair
24.11 Infections of the central nervous system 6060 24.11.1 Bacterial infections 6060 Diederik van de Beek and Guy E. Thwaites
24.11.2 Viral infections 6082 Fiona McGill, Jeremy Farrar, Bridget Wills, Menno De Jong, David A. Warrell, and Tom Solomon
24.11.3 Intracranial abscesses 6097 Tim Lawrence and Richard S.C. Kerr
24.11.4 Neurosyphilis and neuro- AIDS 6100 Hadi Manji
24.11.5 Human prion diseases 6109 Simon Mead and R.G. Will
24.12 Disorders of cranial nerves 6120 Robert D.M. Hadden
24.13 Disorders of the spinal cord 6127 24.13.1 Diseases of the spinal cord 6127 Anu Jacob and Andrew J. Larner
24.13.2 Spinal cord injury and its management 6135 Wagih El Masri(y) and Michael Barnes
24.14 Diseases of the autonomic nervous system 6150 Christopher J. Mathias and David A. Low
24.15 The motor neuron diseases 6166 Tom Jenkins, Alice Brockington, and Pamela J. Shaw
24.16 Diseases of the peripheral nerves 6176 Robert D.M. Hadden
24.17 Inherited neurodegenerative diseases 6197 Swati Sathe
24.18 Disorders of the neuromuscular junction 6295 David Hilton- Jones and Jacqueline Palace
24.19 Disorders of muscle 6304 24.19.1 Structure and function of muscle 6304 Michael G. Hanna and Enrico Bugiardini
24.19.2 Muscular dystrophy 6310 Kate Bushby and Chiara Marini- Bettolo
24.19.3 Myotonia 6328 David Hilton- Jones
David Hilton- Jones 24.19.4 Metabolic and endocrine disorders 6334 David Hilton- Jones and Richard Edwards
24.19.5 Mitochondrial disease 6343 Patrick F. Chinnery and D.M. Turnbull
Patrick F. Chinnery and D.M. Turnbull Developmental abnormalities of the central nervous system 6350 Chris M. Verity, Jane A. Hurst, and Helen V. Firth
24.21 Acquired metabolic disorders and the nervous system 6368 Neil Scolding
Neurological complications of systemic disease 6376 Neil Scolding
24.23 Paraneoplastic neurological syndromes 6384 Jeremy Rees
24.24 Autoimmune encephalitis and Morvan’s syndrome 6393 Camilla Buckley and Angela Vincent
SECTION 25 Disorders of the eye Section editor: Christopher P. Conlon
25.1 The eye in general medicine 6399 Tasanee Braithwaite, Richard W.J. Lee, and Peng T. Khaw
SECTION 26 Psychiatric and drug- related disorders Section editor: Michael Sharpe
26.1 General introduction 6445 Michael Sharpe
26.2 The psychiatric assessment of the medical patient 6447 Jane Walker, Roger Smyth, and Michael Sharpe
26.3 Common psychiatric presentations in medical patients 6454 26.3.1 Confusion 6454 Bart Sheehan and Thomas Jackson
26.3.2 Self- harm 6457 Kate E.A. Saunders and Keith Hawton
26.3.3 Medically unexplained symptoms 6460 Michael Sharpe
26.3.4 Low mood 6462 Jane Walker
26.4 Psychiatric treatments in the medically ill 6465 26.4.1 Psychopharmacology in medical practice 6465 Philip J. Cowen
26.4.2 Psychological treatments 6470 Michael Sharpe and Simon Wessely
26.5 Specific psychiatric disorders 6475 26.5.1 Delirium 6475 Bart Sheehan
26.5.2 Dementia 6478 Bart Sheehan
26.5.3 Organic psychoses 6482 Curtis McKnight and Jason Caplan
26.5.4 Alcohol misuse 6486 Jonathan Wood
26.5.5 Substance misuse 6490 Stephen Potts
26.5.6 Depressive disorder 6493 Joseph Cerimele and Lydia Chwastiak
26.5.7 Bipolar disorder 6498 Kate E.A. Saunders and John Geddes
26.5.8 Anxiety disorders 6501 Ted Liao and Steve Epstein
26.5.9 Acute stress disorder, adjustment disorders, and post- traumatic stress disorder 6506 Jonathan I. Bisson
26.5.10 Eating disorders 6509 Christopher G. Fairburn
26.5.11 Schizophrenia 6513 Stephen M. Lawrie
26.5.12 Somatic symptom and related disorders 6517 Michael Sharpe
26.5.13 Personality disorders 6520 Iain Jordan
26.6 Changing unhealthy behaviours 6524 26.6.1 Brief interventions for excessive alcohol consumption 6524 Amy O’Donnell, Eileen Kaner, and Nick Heather
26.6.2 Obesity and weight management 6529 Susan Jebb and Paul Aveyard
26.6.3 Smoking cessation 6533 Paul Aveyard
Paul Aveyard 26.7 Psychiatry, liaison psychiatry, and psychological medicine 6536 Michael Sharpe
SECTION 27 Forensic medicine Section editor: John D. Firth
27.1 Forensic and legal medicine 6541 Jason Payne- James, Paul Marks, Ralph Bouhaidar, and Steven B. Karch
SECTION 28 Sport and exercise Section editor: John D. Firth
28.1 Sport and exercise medicine 6565 Cathy Speed
SECTION 29 Biochemistry in medicine Section editor: Christopher P. Conlon
29.1 The use of biochemical analysis for diagnosis and management 6577 Brian Shine and Nishan Guha
SECTION 30 Acute medicine Section editor: John D. Firth
30.1 Acute medical presentations 6591 Sian Coggle, Elaine Jolly, and John D. Firth
30.2 Practical procedures 6644 Elaine Jolly, Sian Coggle, and John D. Firth
Index
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