Drug-induced hepatitis is the inflammation of the liver parenchyma attributable to the consumption of sure medicines. The liver is likely one of the busiest organs of the human physique. One of many essential capabilities of the liver is detoxing and elimination of medication by subjecting them to chemical processes i.e biotransformation (rendering nonpolar substances to polar ones, thus serving to their excretion) and alterations of their organic exercise. On this article, we’re going to share with you medicine that trigger hepatitis mnemonics as a way to simply bear in mind all circumstances of drug-induced hepatitis to your exams.
But before we go to the mnemonics for drugs that cause hepatitis, let’s a look at the mechanism of hepatic drug metabolism:
Notice the “ACTIVE METABOLITE”, which causes liver damage/hepatitis. One of the common examples of highly active metabolite is N-Acetyl Para Benzoquinone Imine(NAPQI), a toxic byproduct produced by the metabolism of Paracetamol. Normally, the NAPQI is produced in very small quantities and is immediately detoxified and eliminated from the body. But in some conditions (i.e Paracetamol overdose), NAPQI is not efficiently detoxified and thus causes severe liver damage leading to fulminant liver failure and ultimately causing death.
Alright, now without further ado, let’s get to our main topic.
Drugs that Cause Hepatitis Mnemonics
Below are the mnemonics for drugs that cause hepatitis:
E: PhenYtoin (sounds like “E”)
Mnemonic: FAT PINK CARS
F: Fe (Iron salts)
K: Ketoconazole (and other antifungals, esp Itraconazole)
A: Anaesthetic agents (esp Halothane)
S: Statins (HMG CoA inhibitors)